Animal replica research haven't been performed Using the drug combination-promethazine and codeine. It's not at all acknowledged no matter whether this drug mix could cause fetal harm when administered to some pregnant girl or can have an effect on replica potential.
Promethazine HCl and Codeine Phosphate Oral Answer must be made use of with warning in people with impairment of hepatic perform, and clients needs to be monitored closely for respiratory despair, sedation, and hypotension.
Most of the research, both constructive and detrimental, were constrained by modest sample size, remember bias and deficiency of data regarding dose and timing of publicity.
Prevention and Charge of nausea and vomiting connected to particular different types of anesthesia and operation.
Promethazine and codeine may possibly induce marked drowsiness or may impair the mental and/or physical abilities expected for your overall performance of doubtless hazardous duties, like driving a car or working equipment.
Long-phrase animal experiments haven't been performed to evaluate the carcinogenic potential of promethazine, nor are there other animal or human info regarding carginogenicity, mutagenicity, or impairment of fertility with this drug. Promethazine was nonmutagenic within the Salmonella exam system of Ames.
g., Those people with evidence of amplified intracranial pressure or Mind tumors), Promethazine HCl and Codeine Phosphate Oral Solution might minimize respiratory generate, plus the resultant CO2 retention can further more increase intracranial pressure. Additionally, opioids produce adverse reactions which could obscure check here the scientific study course of sufferers with head accidents.
Very long-time period animal research have not been carried out to evaluate the carcinogenic opportunity of Promethazine, nor are there other animal or human info relating to carcinogenicity, mutagenicity, or impairment of fertility with this particular drug. Promethazine was nonmutagenic in the Salmonella exam procedure of Ames.
Warning must be exercised when administering Promethazine HCl Oral Alternative to pediatric sufferers two many years of age and more mature due to potential for deadly respiratory depression. Respiratory melancholy and apnea, in some cases connected with Loss of life, are strongly associated with Promethazine goods and therefore are circuitously linked to individualized bodyweight-centered dosing, which could usually allow Protected administration.
It can be soluble in drinking water and freely soluble in alcohol. It's got a molecular fat of 320.88, a molecular formulation of C17H20N2S•HCl, and the following structural formula:
It is important that Promethazine HCl Oral Option is measured by having an accurate measuring device (see Safeguards-Information and facts for Sufferers). A house teaspoon is not really an exact measuring gadget and could lead on to overdosage, particularly when 50 % a teaspoon is always to be measured.
Promethazine is often a phenothiazine derivative which differs structurally from the antipsychotic phenothiazines via the presence of the branched aspect chain and no ring substitution.
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